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Das Forschungszentrum für das Kind FZK

Das Forschungzentrum (FZK) hat sich zum Ziel gesetzt, beste Ergebnisse in den relevanten Bereichen Prävention, Wiederherstellung und Heilung von Krankheiten, Verletzungen und Fehlbildungen zu erreichen, und zwar vom Neugeborenen bis zum Jugendlichen.

Translational Brain Tumor Research Group

 

Brain tumors are the most common solid tumors in children and adolescents. They are often challenging to cure and remain the main cause of cancer-related death and morbidity in young patients.

 

After surgery, treatment often consists of combination of chemotherapy and/or radiotherapy. Cytotoxic therapies can have long-lasting side effects due to their impact in the developing child and central nervous system. Moreover, these treatments are not always successful at controlling tumor growth. Even after initial tumor shrinkage, some tumors become resistant to treatment and are incurable at relapse.

 

Our group brings together laboratory and clinical research, working closely with international collaborators, to bring new insights into brain tumor pathogenesis and accelerate translation into clinical investigation. Our overarching goal is to optimize therapies, improve survival of pediatric brain tumor patients and increase the quality of life for survivors.

 

Our main areas of research are:

  1. Discovery of novel mechanisms of pediatric brain tumor pathogenesis and development of innovative, mechanism-based therapeutic strategies.   
  2. Investigation of causes of drug resistance and treatment failure.
  3. Longitudinal study of health-related outcomes and long-term impact of current therapies.

 

Group members:

Dr. med. Dr. sc. nat. Ana Guerreiro Stücklin, Principal Investigator

ana.stuecklin@kispi.uzh.ch

Dr. sc. ETH Andreas Postlmayr, Postdoctoral Researcher

andreas.postlmayr@kispi.uzh.ch

M Med Sarah Metzger, Doktorandin

sarah.metzger@kispi.uzh.ch

PharmD Monica Capogiri, PhD Candidate

monica.capogiri@kispi.uzh.ch

Dr. Annette Weiser, Neurooncology Clinical and Research Fellow

annette.weiser@kispi.uzh.ch

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